ゲノム動態研究部門
theses_title1
研究室紹介
メンバー
学術論文
原著論文
総説・著書
国際学会での招待講演
シンポジウム企画・レビュウ学会誌
教育と進路
内部連絡
科学研究費補助金　基盤研究S
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原著論文（5年間） | 原著論文　（過去の代表的論文）

原著論文（5年間）

  • (1) Kawamura K, Qi F, Meng Q, Hayashi I, Kobayashi J. Nucleolar protein nucleolin functions in replication stress-induced DNA damage responses. J Radiat Res, in press. 2019
  • (2) Shimura T, Sasatani M, Kawai H, Kamiya K, Kobayashi J, Komatsu K, Kunugita N. Radiation-Induced Myofibroblasts Promote Tumor Growth via Mitochondrial ROS-Activated TGFβ Signaling. Mol Cancer Res. 16:1676-1686, 2018
  • (3) Masunaga S, Kobayashi J, Tano K, Sanada Y, Suzuki M, Ono K. The Effect of p53 Status on Radio-Sensitivity of Quiescent Tumor Cell Population Irradiated With γ-Rays at Various Dose Rates. J Clin Med Res. 10: 815-821, 2018
  • (4) Iijima K, Kobayashi J, Ishizaka Y. Structural alteration of DNA induced by viral protein R of HIV-1 triggers the DNA damage response. Retrovirology. 15, e8, 2018
  • (6) Shimura T, Sasatani M, Kawai H, Kamiya K, Kobayashi J, Komatsu K, Kunugita N. ATM-mediated mitochondrial damage response triggered by nuclear DNA damage in normal human lung fibroblasts. Cell Cycle, 16, 2345-2354, 2017
  • (7) Igarashi K, Kobayashi J, Katsumura T, Urushihara Y, Hida K, Watanabe-Asaka T, Oota H, Oda S, Mitani H. An Approach to Elucidate NBS1 Function in DNA Repair Using Frequent Nonsynonymous Polymorphism in Wild Medaka (Oryzias latipes) Populations. PLoS One 12:e0170006, 2017.
  • (8) Shimura T, Sasatani M, Kawai H, Kamiya K, Kobayashi J, Komatsu K, Kunugita N. A comparison of radiation-induced mitochondrial damage between neural progenitor stem cells and differentiated cells. Cell Cycle 16:565-573, 2017.
  • (9) Zhou H, Kawamura K, Yanagihara H, Kobayashi J, Zhang-Akiyama Q. NBS1 is regulated by two kind of mechanisms; ATM-dependent complex formation with MRE11 and RAD50 and cell cycle dependent-degradation of protein. J Radiat Res 58:487-494, 2017.
  • (10) Katoh S, Kobayashi J, Umeda T, Kobayashi Y, Nobuo I and Suzuki T. Chronic irradiation with low-dose-rate 137Cs-γ rays inhibits NGF-induced neurite extension of PC12 cells via Ca2+/calmodulin-dependent kinase II activation. J Radiat Res, 58, 809-815, 2017
  • (11) Shimada M, Matsuzaki F, Kato A, Kobayashi J, Matsumoto T, Komatsu K. Induction of Excess Centrosomes in Neural Progenitor Cells during the Development of Radiation-Induced Microcephaly. PLoS One 11:e0158236, 2016.
  • (12) Shimura T, Kobayashi J, Komatsu K, Kunugita N. Severe mitochondrial damage associated with low-dose radiation sensitivity in ATM- and NBS1-deficient cells. Cell Cycle 15:1099-1107, 2016.
  • (13) Kobayashi J, Saito Y, Okui M, Miwa N, Komatsu K. Increased oxidative stress in AOA3 cells disturbs ATM-dependent DNA damage responses. Mutat Res Genet Toxicol Environ Mutagen 782:42-50, 2015.
  • (14) Hoa NN, Kobayashi J, Omura M, Hirakawa M, Yang SH, Komatsu K, Paull TT, Takeda S, Sasanuma H. BRCA1 and CtIP Are Both Required to Recruit Dna2 at Double-Strand Breaks in Homologous Recombination. PLoS One 10:e0124495, 2015.
  • (15) Kamimura D, Katsunuma K, Arima Y, Atsumi T, Jiang J, Bando H, Meng J, Sabharwal L, Stofkova A, Nishikawa N, Suzuki H, Ogura H, Ueda N, Tsuruoka M, Harada M, Kobayashi J, Hasegawa T, Yoshida H, Koseki H, Miura I, Wakana S, Nishida K, Kitamura H, Fukada T, Hirano T, Murakami M. KDEL receptor 1 regulates T-cell homeostasis via PP1 that is a key phosphatase for ISR. Nature Commun 6:7474, 2015.
  • (16) Yoshikawa Y, Yamasaki A, Takatori K, Suzuki M, Kobayashi J, Takao M, Zhang-Akiyama QM. Excess processing of oxidative damaged bases hypersensitivity to oxidative stress and low dose rate irradiation. Free Radic Res 49, 1239-1248, 2015.
  • (17) Iwahori S, Kohmon D, Kobayashi J, Tani Y, Yugawa T, Komatsu K, Kiyono T, Sugimoto N, Fujita M. ATM regulates Cdt1 stability during the unperturbed S phase to prevent re-replication. Cell Cycle 13:471–481, 2014.
  • (18) Oliveira DV, Kato A, Nakamura K, Ikura T, Okada M, Kobayashi J, Yanagihara H, Saito Y, Tauchi H, Komatsu K. Histone chaperone FACT regulates homologous recombination by chromatin remodeling through interaction with RNF20. J Cell Sci 127:763-772, 2014.
  • (19) Su F, Mukherjee S, Yang Y, Mori E, Bhattacharya S, Kobayashi J, Yannone SY, Chen DJ, Asaithamby A. Nonenzymatic Role for WRN in Preserving Nascent DNA Strands after Replication Stress. Cell reports 9:1387-1401, 2014.
  • (20) Yoshida T, Awaya T, Shibata M, Kato T, Numabe H, Kobayashi J, Komatsu K, Heike T. Hypergonadotropic Hypogonadism and Hypersegmented Neutrophils in a Patient with Ataxia-Telangiectasia-Like Disorder: Potential Diagnostic Clues? Am J Med Genet A 164:1830-1834, 2014
  • (21) Hirota K, Tsuda M, Murai J, Takagi T, Keka IS, Narita T, Fujita M, Sasanuma H, Kobayashi J, Takeda S. SUMO-targeted ubiquitin ligase RNF4 plays a critical role in preventing chromosome loss. Genes Cells 19:743-754, 2014.
  • (22) Saito Y, Takeda J, Adachi K, Nobe Y, Kobayashi J, Hirota K, Oliveira DV, Taoka M, Isobe T. RNase MRP Cleaves Pre-tRNASer-Met in the tRNA Maturation Pathway. PLoS ONE 9:e112488, 2014.
  • (23) Shimura T, Kobayashi J, Komatsu K, Kunugida N. DNA damage signaling guards against perturbation of cyclin D1 expression triggered by low-dose long-term fractionated radiation. Oncogenesis 3:e132, 2014.
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原著論文　（過去の代表的論文）

  • Kondo T, Kobayashi J, Saitoh T, Maruyama K, Ishii KJ, Barber GN, Komatsu K, Akira S, Kawai T. DNA damage sensor MRE11 recognizes cytosolic double-stranded DNA and induces type I interferon by regulating STING trafficking. Proc Natl Acad Sci USA 110:2969-2974 2013.
  • Yoshiyama KO, Kobayashi J, Ogita N, Ueda M, Kimura S, Maki H, Umeda M. ATM-mediated phosphorylation of SOG1 is essential for the DNA damage response in Arabidopsis. EMBO Rep 14:817-822, 2013
  • Yanagihara H, Kobayashi J, Tateishi S, Kato A, Matsuura S, Tauchi H, Yamada K, Takezawa J, Sugasawa K, Masutani C, Hanaoka F, Weemaes CM, Mori T, Zou L, Komatsu K. NBS1 Recruits RAD18 via a RAD6-like Domain and Regulates Pol η-Dependent Translesion DNA Synthesis. Mol Cell 43:788-797, 2011.
  • Nakamura K, Kato A, Kobayashi J, Yanagihara H, Sakamoto S, Oliveira D, Shimada S, Tauchi H, Suzuki H, Tashiro S, Zou L, Komatsu K. Regulation of homologous recombination by RNF20-dependent H2B ubiquitination. Mol Cell 41:515-528, 2011.
  • Kobayashi J, Antoccia A, Tauchi H, Matsuura S, Komatsu K. Nbs1 and its Functional Role in the DNA Damage Response. DNA Repair, 3:855-861, 2004
  • Iijima K, Komatsu K, Matsuura S, Tauchi H. The Nijmegen breakage syndrome gene and its role in genome stability. Chromosoma, 113:53-61, 2004
  • Tauchi H, Kobayashi J, Morishima K, van Gent DC, Shiraishi T, Verkalk NS, van Heems D, Itoh E, Nakamura A, Sonoda E, Takata M, Takeda S, Matsuura S, Komatsu K. Nbs1 is essential for DNA repair by homologous recombination in higher vertebrate cells. Nature, 420:93-98, 2002
  • Kobayashi J, Tauchi H, Sakamoto S, Nakmaura A, Morishima K, Matsuura S, Kobayashi T, Tamai K, Tanimoto K, Komatsu K. NBS1 localizes to γH2AX foci through interaction with the FHA/BRCT domain. Curr Biol, 12:1846-1851, 2002
  • Tauchi H, Matsuura S, Kobayashi J, Sakamoto S, Komatsu K. Nijmegen breakage syndrome gene, NBS1, and moleculer links to factors for genome stability. Oncogene, 21:8967-8980, 2002
  • Tauchi H, Kobayashi J, Morishima K, Matsuura S, Nakamura A, Shiraishi T, Ito E, Masnada D, Delia D, Komatsu K. The FHA domain of NBS1 is essential for nuclear foci formation after irradiation, but not essential for hRAD50/hMRE11/NBS1 complex DNA Repair activity. J Biol Chem, 276: 12-15, 2001
  • Matsuura S, Tauchi H, Nakamura A, Kondo N, Sakamoto S, Endo S, Smeets D, Solder B, Belohradsky BH, Kaloustian VMD, Oshimura M, Isomura M, Nakamura Y, Komatsu K. Positional cloning of the gene for Nijmegen breakage syndrome. Nature Genet, 19: 179-181, 1998
  • Imai H, Nakagama H, Komatsu K, Shiraishi T, Fukuda H, Sugimura T, Nagao M. Minisatellite instability in severe combined immunodeficiency mouse cells. Proc Natl Acad Sci USA, 94: 10817-10820, 1997
  • Komatsu K, Kubota N, Gallo M, Okumura Y, Lieber MR. The scid Factor on Human Chromosome 8 Restores V(D)J Recombination in Addition to Double-Strand Break Repair. Cancer Res, 55:1774-1779, 1995
  • Taniguchi S, Hirabayashi Y, Inoue T, Kanisawa M, Komatsu K, Mori KJ. Hemopoetic stem-cell compartmant of the SCID mouse:Double-exponential survival curve after gamma irradiation. Proc Natl Acad Sci USA, 90: 4354-4358, 1993
  • Komatsu K, Ohta T, Jinno Y, Niikawa N, Okumura Y. Functional complementation in mouse-human radiation hybrids assigns the putative murine scid gene to the pericentric region of human chromosome 8. Hum Mol Genet, 2:1031-1034, 1993
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